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New hormone therapies for hot flashes offer enhanced benefits and minimized risk (scienmag.com)

MODEL RELEASED. Hormone replacement therapy (HRT) patch. Doctor sticking an HRT patch on a patient's arm. HRT is a treatment that replaces the female sex hormones oestrogen and progesterone with synthetic versions, reducing the symptoms of the menopause. These include hot flushes, night sweating and atrophic vaginitis (vaginal dryness). HRT also helps prevent atherosclerosis (arterial narrowing due to fatty deposits) and osteoporosis (loss of bone density). Treatment is normally given for two to five years.

Hormone therapy remains the best proven method for managing menopause symptoms such as hot flashes. Research continues, however, in the area to identify novel approaches to estrogen therapy that minimize any associated risks. Dr. Hugh Taylor from Yale School of Medicine will discuss some of the latest developments, including fetal estrogens, during the 2020 Pre-Meeting Symposium of The North American Menopause Society (NAMS).

According to Dr. Taylor, a number of improvements have been introduced in the past decade. These include new selective estrogen receptor modulators (SERMs) and the use of estrogens together with SERMs to replace progestins. Fetal estrogens represent one of the newest promising developments. Their unique properties distinguish them from estradiol, although they have some SERM-like properties.

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Hormone therapy, long shunned for a possible breast cancer link, is now seen as a short-term treatment for menopause symptoms (www.washingtonpost.com)

Hormone replacement therapy: Uses, types, and alternatives (www.medicalnewstoday.com)